Frequency and Associated Risk Factors of Stroke Among Neurological Disorders in Rawalpindi and Islamabad
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Background: Stroke is a major contributor to neurological morbidity, disability, and healthcare burden, particularly in low- and middle-income settings where modifiable vascular and metabolic risk factors remain highly prevalent. Objective: To determine the frequency of stroke among adult patients with neurological disorders in selected hospitals and clinics of Rawalpindi and Islamabad and to describe the risk-factor profile of patients diagnosed with ischemic or hemorrhagic stroke. Methods: A descriptive cross-sectional study was conducted over six months among 377 adult neurological patients recruited from selected healthcare facilities. Demographic characteristics, neurological diagnosis, stroke status, stroke subtype, episode history, and common vascular risk factors were recorded using a structured questionnaire and available medical documentation. Data were analyzed using SPSS version 26, with categorical variables summarized as frequencies and percentages and age summarized as mean ± standard deviation. Results: The mean age of participants was 53.53 ± 15.80 years; 217 (57.56%) were male and 236 (62.60%) were urban residents. Stroke was identified in 149 participants, giving a frequency of 39.52%. Among stroke cases, 105 (70.47%) had ischemic stroke and 44 (29.53%) had hemorrhagic stroke. One-time stroke was reported by 117 (78.52%) patients, while recurrent episodes were reported by 32 (21.47%). Hypertension was the most frequent risk factor among stroke patients (80.54%), followed by obesity (58.39%), diabetes mellitus (56.38%), family history of stroke (44.30%), smoking history (35.57%), high cholesterol (30.20%), and heart disease (28.19%). Conclusion: Stroke represented the largest diagnostic category among neurological patients in this facility-based sample, with ischemic stroke predominating and a high burden of modifiable cardiometabolic risk factors among stroke cases.
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1. Mukherjee S, Ali S, Hashmi S, Jahan S. History, origin and types of neurological disorders. In: Applications of stem cells and derived exosomes in neurodegenerative disorders. Singapore: Springer; 2023. p. 1-32.
2. Singh RJ, Chen S, Ganesh A, Hill MD. Long-term neurological, vascular, and mortality outcomes after stroke. Int J Stroke. 2018;13(8):787-96.
3. Ngarka L, Siewe Fodjo JN, Aly E, Masocha W, Njamnshi AK. The interplay between neuroinfections, the immune system and neurological disorders: a focus on Africa. Front Immunol. 2022;12:803475.
4. Nejad SH, Roffman JL, Kueppenbender K, Smith FA, Huffman JC, Stern TA. Patients with neurologic conditions II: movement disorders, multiple sclerosis, and other neurologic conditions. In: Massachusetts General Hospital Handbook of General Hospital Psychiatry. 6th ed. Philadelphia: Saunders Elsevier; 2010. p. 255-72.
5. Deleidi M, Jäggle M, Rubino G. Immune aging, dysmetabolism, and inflammation in neurological diseases. Front Neurosci. 2015;9:172.
6. Leibetseder A, Eisermann M, LaFrance WC Jr, Nobili L, von Oertzen TJ. How to distinguish seizures from non-epileptic manifestations. Epileptic Disord. 2020;22(6):716-38.
7. Chen T, Giri M, Xia Z, Subedi YN, Li Y. Genetic and epigenetic mechanisms of epilepsy: a review. Neuropsychiatr Dis Treat. 2017;13:1841-59.
8. Roy A, Chatterjee S. Epileptic seizures. In: MIMICS of Epileptic Seizures. 2020. p. 180.
9. Huff HV, Huff KR. Seizures and epilepsy. In: Berkowitz’s Pediatrics: A Primary Care Approach. 6th ed. Itasca: American Academy of Pediatrics; 2020. p. 982.
10. Chaudhary UJ, Diehl B. The spectrum of seizures and epilepsies. In: Epilepsy: A Queen Square Textbook. 2026. p. 14-30.
11. Ramesh S, Arachchige ASPM. Depletion of dopamine in Parkinson’s disease and relevant therapeutic options: a review of the literature. AIMS Neurosci. 2023;10(3):200.
12. Coleman JC. Rethinking Parkinson’s Disease: The Definitive Guide to the Known Causes of Parkinson’s Disease and Proven Reversal Strategies. Melbourne: Hybrid Publishers; 2020.
13. Dias V, Junn E, Mouradian MM. The role of oxidative stress in Parkinson’s disease. J Parkinsons Dis. 2013;3(4):461-91.
14. Jankovic J, Lang AE. Diagnosis and assessment of Parkinson disease and other movement disorders. In: Bradley’s Neurology in Clinical Practice. 2021;24:310-33.
15. Goldman JG. Non-motor symptoms and treatments in Parkinson’s disease. Neurol Clin. 2025;43(2):291-317.
16. Zvěřová M. Clinical aspects of Alzheimer’s disease. Clin Biochem. 2019;72:3-6.
17. Ávila-Villanueva M, Marcos Dolado A, Gómez-Ramírez J, Fernández-Blázquez M. Brain structural and functional changes in cognitive impairment due to Alzheimer’s disease. Front Psychol. 2022;13:886619.
18. Leszek J, Mikhaylenko EV, Belousov DM, Koutsouraki E, Szczechowiak K, Kobusiak-Prokopowicz M, et al. The links between cardiovascular diseases and Alzheimer’s disease. Curr Neuropharmacol. 2021;19(2):152-69.
19. Budson AE, Solomon PR. Memory Loss, Alzheimer’s Disease, and Dementia: A Practical Guide for Clinicians. Philadelphia: Elsevier Health Sciences; 2021.
20. Burgio L, Allen-Burge R, Stevens A, Davis L, Marson D. Caring for Alzheimer’s disease patients: issues of verbal communication and social interaction. In: The Gerontological Prism. London: Routledge; 2018. p. 231-58.
21. Zéphir H. Progress in understanding the pathophysiology of multiple sclerosis. Rev Neurol. 2018;174(6):358-63.
22. Olsson T, Barcellos LF, Alfredsson L. Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis. Nat Rev Neurol. 2017;13(1):25-36.
23. Correale J, Gaitán M. Multiple sclerosis and environmental factors: the role of vitamin D, parasites, and Epstein-Barr virus infection. Acta Neurol Scand. 2015;132:46-55.
24. Koldanov N. Early typical and atypical multiple sclerosis symptoms [dissertation]. Kaunas: Lithuanian University of Health Sciences; 2022.
25. Patel D. Experiences of relapsing remitting multiple sclerosis and disease modifying treatment: a phenomenological inquiry [dissertation]. London: University of East London; 2021.
26. Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, et al. Diabetic neuropathy. Nat Rev Dis Primers. 2019;5(1):41.
27. Babel RA, Dandekar MP. A review on cellular and molecular mechanisms linked to the development of diabetes complications. Curr Diabetes Rev. 2021;17(4):457-73.
28. Yavuz DG. Classification, risk factors, and clinical presentation diabetic neuropathy. In: Diabetic Neuropathy. Amsterdam: Elsevier; 2022. p. 1-9.
29. Mauermann ML, Staff NP. Peripheral neuropathy: a review. JAMA. 2026;335(3):255-66.
30. Bianchi L, Volpato S. Muscle dysfunction in type 2 diabetes: a major threat to patient’s mobility and independence. Acta Diabetol. 2016;53(6):879-89.
31. Murphy SJ, Werring DJ. Stroke: causes and clinical features. Medicine. 2020;48(9):561-6.
32. Warlow C. Epidemiology of stroke. Lancet. 1998;352 Suppl 3:S1-4.
33. Coupland AP, Thapar A, Qureshi MI, Jenkins H, Davies AH. The definition of stroke. J R Soc Med. 2017;110(1):9-12.
34. Markus H. Stroke: causes and clinical features. Medicine. 2008;36(11):586-91.
35. Adamson J, Beswick A, Ebrahim S. Is stroke the most common cause of disability? J Stroke Cerebrovasc Dis. 2004;13(4):171-7.
36. Sherin A, Ul-Haq Z, Fazid S, Shah BH, Khattak MI, Nabi F. Prevalence of stroke in Pakistan: findings from Khyber Pakhtunkhwa Integrated Population Health Survey 2016-17. Pak J Med Sci. 2020;36(7):1435-40.
37. Tiseo C. Epidemiology of ischemic stroke subtypes: results from the follow-up of a population-based registry [dissertation]. 2020.
38. Adebayo O, Akpa O, Asowata OJ, Fakunle A, Sarfo FS, Akpalu A, et al. Determinants of first-ever stroke severity in West Africans: evidence from the SIREN Study. J Am Heart Assoc. 2023;12(12):e027888.
39. Sacco RL, Kargman DE, Gu Q, Zamanillo MC. Race-ethnicity and determinants of intracranial atherosclerotic cerebral infarction: the Northern Manhattan Stroke Study. Stroke. 1995;26(1):14-20.
40. Ho FK, Gray SR, Welsh P, Gill JM, Sattar N, Pell JP, et al. Ethnic differences in cardiovascular risk: examining differential exposure and susceptibility to risk factors. BMC Med. 2022;20(1):149.
41. Miah MNA, Azhar MA, Rahman A, Halder D, Akteruzzaman M, Kundu NC. Risk factors of stroke in young and old age group: a comparative study. J Med. 2012;13(2):138-42.
42. Demel SL, Kittner S, Ley SH, McDermott M, Rexrode KM. Stroke risk factors unique to women. Stroke. 2018;49(3):518-23.
43. Xia W, Khalil RA. Hormone replacement therapy and cardiovascular health in postmenopausal women. Int J Mol Sci. 2025;26(11):5078.
44. Hankey GJ. Population impact of potentially modifiable risk factors for stroke. Stroke. 2020;51(3):719-28.
45. Choudhury MJH, Chowdhury MTI, Nayeem A, Jahan WA. Modifiable and non-modifiable risk factors of stroke: a review update. J Natl Inst Neurosci Bangladesh. 2015;1(1):22-6.
46. Lee EJ, Kim HJ, Bae JM, Kim JC, Han HJ, Park CS, et al. Relevance of common carotid intima-media thickness and carotid plaque as risk factors for ischemic stroke in patients with type 2 diabetes mellitus. AJNR Am J Neuroradiol. 2007;28(5):916-9.
47. Ozdemir H, Sagris D, Lip GY, Abdul-Rahim AH. Stroke in atrial fibrillation and other atrial dysrhythmias. Curr Cardiol Rep. 2023;25(5):357-69.
48. Iso H, Jacobs DR Jr, Wentworth D, Neaton JD, Cohen JD, Multiple Risk Factor Intervention Trial Research Group. Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the Multiple Risk Factor Intervention Trial. N Engl J Med. 1989;320(14):904-10.
49. Alam S, Aijaz M. Complications of cardiovascular disease: the impact of diabetes, dyslipidemia, and metabolic disorders. World J Pharm Res. 2024;13:321-56.
50. Denti L, Cecchetti A, Annoni V, Merli MF, Ablondi F, Valenti G. The role of lipid profile in determining the risk of ischemic stroke in the elderly: a case-control study. Arch Gerontol Geriatr. 2003;37(1):51-62.
51. Lamoria M, Yadav N, Ayana AM. Pathophysiology of atherosclerosis and its adverse effect: systematic review. 2024.
52. Jetten J, Haslam C, Pugliese C, Tonks J, Haslam SA. Declining autobiographical memory and the loss of identity: effects on well-being. J Clin Exp Neuropsychol. 2010;32(4):408-16.
53. Song YM, Kwon SU, Sung J, Ebrahim S, Smith GD, Sunwoo S, et al. Different risk factor profiles between subtypes of ischemic stroke: a case-control study in Korean men. Eur J Epidemiol. 2005;20:605-12.
54. Shinton R, Beevers G. Meta-analysis of relation between cigarette smoking and stroke. BMJ. 1989;298(6676):789-94.
55. Pellegrino MP, Moreira F, Conforto AB. Ischemic stroke. In: Neurocritical Care for Neurosurgeons: Principles and Applications. Cham: Springer; 2021. p. 517-34.
56. Caprio FZ, Lin C. Unusual causes of ischemic stroke and transient ischemic attack. In: Warlow’s Stroke: Practical Management. 2019. p. 345-98.
57. Unnithan AKA, Das JM, Mehta P. Hemorrhagic stroke. In: StatPearls. Treasure Island: StatPearls Publishing; 2024.
58. Dorrance AM, Fink G. Effects of stroke on the autonomic nervous system. Compr Physiol. 2015;5(3):1241-63.
59. Tang EY, Amiesimaka O, Harrison SL, Green E, Price C, Robinson L, et al. Longitudinal effect of stroke on cognition: a systematic review. J Am Heart Assoc. 2018;7(2):e006443.
60. Lynch EB, Butt Z, Heinemann A, Victorson D, Nowinski CJ, Perez L, et al. A qualitative study of quality of life after stroke: the importance of social relationships. J Rehabil Med. 2008;40(7).
61. Kongkaew J, Sumdaengrit B, Siripitayakunkit A. Symptom experiences, symptom management strategies, and outcomes in patients with stroke. Pak J Life Soc Sci. 2025;23(1).
62. Sun B, Wang Z. A short review on advances in early diagnosis and treatment of ischemic stroke. Galen Med J. 2023;12:e2993.
63. Shafaat O, Sotoudeh H. Stroke imaging. In: StatPearls. Treasure Island: StatPearls Publishing; 2023.
64. David E, Grazhdani H, Aliotta L, Gavazzi LM, Foti PV, Palmucci S, et al. Imaging of carotid stenosis: where are we standing? Comparison of multiparametric ultrasound, CT angiography, and MRI angiography, with recent developments. Diagnostics. 2024;14(16):1708.
65. Zhang M, Long Z, Liu P, Qin Q, Yuan H, Cao Y, et al. Global burden and risk factors of stroke in young adults, 1990 to 2021: a systematic analysis of the Global Burden of Disease Study 2021. J Am Heart Assoc. 2025;14(10):e039387.
66. Gulzar S, Kiani BH, Akram RW, Hussein AM, Alamri A. Gender-based differences in stroke types and risk factors among young adults: a comparative retrospective analysis. J Clin Med. 2025;14(3):663.
67. Jiang C, Chen T, Xiang J, Pang Y. Association between physical activity levels and stroke risk among Chinese adults aged 45 and over based on CHARLS. Sci Rep. 2024;14(1):31739.
68. Wang R, Yin Y, Zhang H, Pan L, Zhu Y, Wang M, et al. Risk factors associated with the prevalence of neck and shoulder pain among high school students: a cross-sectional survey in China. 2023;24(1):641.
69. Rêgo A, Nannoni S, Scherz A, Eskandari A, Salerno A, Pereira M, et al. Undiagnosed major risk factors in acute ischaemic stroke patients: frequency, profile, stroke mechanisms and outcome. Eur J Neurol. 2024;31(1):e16011.
70. Pandian JD, Srivastava MVP, Aaron S, Ranawaka UK, Venketasubramanian N, Sebastian IA, et al. The burden, risk factors and unique etiologies of stroke in South-East Asia Region. Lancet Reg Health Southeast Asia. 2023;17.
71. Ghozy S, Zayan AH, El-Qushayri AE, Parker KE, Varney J, Kallmes KM, et al. Physical activity level and stroke risk in US population: a matched case-control study of 102,578 individuals. Ann Clin Transl Neurol. 2022;9(3):264-75.
72. Akpalu A, Sarfo FS, Akinyemi J, Wahab K, Komolafe M, Obiako R, et al. Frequency and factors associated with recurrent stroke in Ghana and Nigeria. J Neurol Sci. 2022;439:120303.
73. Mori T, Yoshioka K, Tanno Y. Non-alcoholic fatty liver disease frequency and associated factors at admission of acute stroke. Hepatol Int. 2022;16(1):81-8.
74. Sarfo FS, Akinyemi J, Akpalu A, Wahab K, Yaria J, Adebayo O, et al. Frequency and factors associated with post-stroke seizures in a large multicenter study in West Africa. J Neurol Sci. 2021;427:117535.
75. Dabilgou AA, Dravé A, Kyelem JMA, Ouedraogo S, Napon C, Kaboré J. Frequency and mortality risk factors of acute ischemic stroke in emergency department in Burkina Faso. Stroke Res Treat. 2020;2020(1):9745206.
76. Khedr EM, Abdelrahman AA, Desoky T, Zaki AF, Gamea A. Post-stroke depression: frequency, risk factors, and impact on quality of life among 103 stroke patients: hospital-based study. Egypt J Neurol Psychiatry Neurosurg. 2020;56(1):66.