Depressive Symptoms and Treatment Adherence in Patients With Chronic Heart Failure Managed in Internal Medicine Clinics: Cross-Sectional Study
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Abstract
Background: Chronic heart failure requires sustained medication use, dietary self-care, and regular follow-up, but depressive symptoms may interfere with these behaviors and remain underrecognized in routine outpatient care. Objective: To assess the prevalence of depressive symptoms among patients with chronic heart failure attending internal medicine clinics and evaluate their association with treatment adherence. Methods: This cross-sectional observational study included 180 adult patients with chronic heart failure attending selected tertiary care hospitals in Rawalpindi, Pakistan. Depressive symptoms were assessed using the Patient Health Questionnaire-9, with a score of ≥10 defining clinically significant depressive symptoms. Treatment adherence was evaluated across medication compliance, dietary adherence, and clinic follow-up domains. Associations were assessed using chi-square testing, and odds ratios with 95% confidence intervals were calculated. Results: Clinically significant depressive symptoms were present in 76 patients (42.2%). Poor adherence was most frequent for dietary recommendations (51.1%), followed by medication compliance (42.2%) and clinic follow-up (32.8%). Patients with depressive symptoms had higher odds of poor medication adherence (OR 4.65, 95% CI 2.46–8.79; p<0.001), poor dietary adherence (OR 5.29, 95% CI 2.76–10.14; p<0.001), and poor clinic follow-up (OR 1.87, 95% CI 1.00–3.51; p=0.047). Poor adherence increased progressively with greater depressive symptom severity. Conclusion: Depressive symptoms were common and significantly associated with poorer treatment adherence among patients with chronic heart failure, particularly for dietary and medication-related self-care. Routine depressive symptom screening and integrated psychosocial support may improve outpatient heart failure management
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