Sonographic Evaluation of Amniotic Fluid Index Among Diabetic and Non-Diabetic Patients
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Abstract
Background: Amniotic fluid index is an important sonographic marker for assessing fetal well-being and detecting abnormalities in amniotic fluid volume during pregnancy. Diabetes mellitus during pregnancy may alter amniotic fluid dynamics through maternal fetal metabolic changes and is commonly associated with increased risk of polyhydramnios Objective: To compare sonographic amniotic fluid index findings among diabetic and non-diabetic pregnant women and assess the distribution of oligohydramnios and polyhydramnios across maternal age groups. Methods: A comparative cross-sectional observational study was conducted among 80 pregnant women in the second and third trimesters at the Department of Radiology, Ch. M. Akram Teaching and Research Hospital, Lahore. Participants were categorized as diabetic or non-diabetic. Amniotic fluid index was assessed using the four-quadrant ultrasound technique. Oligohydramnios was defined as amniotic fluid index ≤5 cm, and polyhydramnios was defined as amniotic fluid index ≥24 cm. Data were analyzed using SPSS version 26.0, and chi-square testing was applied for categorical associations. Results: Of 80 participants, 57 (71.3%) were diabetic and 23 (28.8%) were non-diabetic. Most women were examined in the third trimester, 53 (66.3%). Polyhydramnios was present in 44 participants (55.0%), while oligohydramnios was present in 36 participants (45.0%). Maternal age group was not significantly associated with diabetic status (p=0.257), gestational trimester (p=0.906), oligohydramnios (p=0.884), or polyhydramnios (p=0.180). Conclusion: Sonographic assessment showed a high burden of amniotic fluid abnormalities, with polyhydramnios slightly more frequent than oligohydramnios. Routine AFI monitoring remains clinically valuable, particularly in pregnancies complicated by diabetes.
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1. Masood K, Farooq SM, Fatima H, Naqvi SM, Amna M, Riaz RM, et al. Effect of diabetes on amniotic fluid index: a sonographic case-control study. Front Biomed Technol. 2025 Jan 11.
2. Dastgir A, Naseem E, Jabbar M, Javed S, Hassan MY, Aziz Y. Sonographic evaluation of amniotic fluid index in diabetic and non-diabetic pregnancies during second and third trimesters: a comparative cross-sectional study. J Health Wellness Community Res. 2025 Oct 29:e920.
3. Khanduri S, Chawla H, Khan A, Lnu S, Pathak V, Gupta A, et al. Association and correlation between amniotic fluid index and glucose concentration. Cureus. 2022 Jun 15;14(6).
4. Bakhsh H, Alenizy H, Alenazi S, Alnasser S, Alanazi N, Alsowinea M, et al. Amniotic fluid disorders and the effects on prenatal outcome: a retrospective cohort study. BMC Pregnancy Childbirth. 2021 Jan 22;21(1):75.
5. Shaker AA, Khalid SI, Fawzi HA. The association of amniotic fluid index measurement and pregnancy outcome. Medical Science. 2020;24(105):3035-40.
6. Majid F, Khadija S, Irum S, Yousaf SM. Sonographic association of polyhydramnios with adverse perinatal outcomes in diabetic mothers from 34 to 40 weeks of pregnancy. Eur J Health Sci. 2022;7:25-33.
7. Kofinas A, Kofinas G. Differences in amniotic fluid patterns and fetal biometric parameters in third trimester pregnancies with and without diabetes. J Matern Fetal Neonatal Med. 2006;19(10):633.
8. Vidyasagara M, Chandrashekhar T, Raikar SS. Correlation of amniotic fluid index with fetomaternal outcome. Int J Reprod Contracept Obstet Gynecol. 2021 Aug 1;10(8):3137-42.
9. Moore LE. Amount of polyhydramnios attributable to diabetes may be less than previously reported. World J Diabetes. 2017 Jan 15;8(1).
10. Meet DK, Yadav BK, Khan SA, Bhandari B, Pradhan T, Thapa P, et al. Impact of abnormal amniotic fluid index on maternal and perinatal outcomes in term pregnancies. Medicine. 2025 Oct 24;104(43):e45320.
11. Patel A, Patel HV. Role of amniotic fluid index in pregnancy outcome. Int Arch Integr Med. 2015 Aug 1;2(8).
12. Khooshideh M, Izadi S, Shahriari A, Mirteymouri M. The predictive value of ultrasound assessment of amniotic fluid index, biophysical profile score, nonstress test and foetal movement chart for meconium-stained amniotic fluid in prolonged pregnancies. Age. 2009;27:5-2.
13. Karahanoglu E, Altinboga O, Akpinar F, Gultekin IB, Ozdemirci S, Akyol A, et al. The effect of the amniotic fluid index on the accuracy of ultrasonographic-estimated fetal weight. Ultrasound Q. 2017 Jun 1;33(2):148-52.
14. Magann EF. The amniotic fluid index and single deepest pocket. Obstet Gynecol. 2011;118(6):1289-94.
15. Obiozor AA. Ultrasound evaluation of amniotic fluid index in women with normal pregnancies in Umuahia, Abia State, Nigeria.
16. Bhinder KK, Raheem A, Pervez R, Aqeel R, Soomro S, Jang A. Reference range of amniotic fluid index in primigravidae with gestational age from 37 to 42 weeks in a local Pakistani population. J Islamabad Med Dent Coll. 2022 Jun 30;11(2):114-9.
17. Kasi N, Ambreen S, Awan S, Khushdil A, Noor L, Yaseen N, et al. The implication of different volumes of amniotic fluid in predicting neonatal outcome. Indus J Biosci Res. 2025 Jan 31;3(1):769-74.
18. Onwuzu SW, Eze CU, Ugwu LC, Abonyi OE, Adejoh T. Ultrasound biometry of normal human amniotic fluid index in a Nigerian population. Radiography. 2016 May 1;22(2):e86-92.
19. Shiwani NR. Perinatal outcomes in patients with low amniotic fluid index oligohydramnios: a comparative study.
20. Milani F, Khosousi L, Sharami SH, Shakiba M, Rasoulian J, Attari SM, et al. Evaluation of perinatal outcomes in pregnant women with low amniotic fluid index. J Family Reprod Health. 2023 Dec;17(4):199.
21. Bakhsh H. Impact of amniotic fluid disorders on fetal outcomes. PMC. 2021.
22. Whittington JR, et al. Amniotic fluid volume for maternal and neonate outcomes: a review. Int J Womens Health. 2023. doi:10.2147/IJWH.S.