Prevalence and Risk Factors of Diabetic Foot Syndrome in Patients with Poorly Controlled Type 2 Diabetes Mellitus: A Cross-Sectional Analytical Study

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Haider Khan
Sakina Bibi Silachi
Amena Bibi
Aqsa Elahi
Muqaddas Zubair
Hafiz Yaseen Khan
Noor ul Ain

Abstract

Background: Diabetic foot syndrome is a disabling and potentially preventable complication of type 2 diabetes mellitus, particularly among patients with poor glycemic control, where neuropathic, vascular, metabolic, and infectious factors contribute to ulceration and limb-threatening complications. Objective: To determine the prevalence of diabetic foot syndrome and identify associated risk factors among patients with poorly controlled type 2 diabetes mellitus. Methods: A hospital-based cross-sectional analytical study was conducted among 320 adults with poorly controlled type 2 diabetes mellitus. Demographic, clinical, anthropometric, and biochemical data were collected using a structured proforma. All participants underwent diabetic foot assessment, including evaluation for peripheral neuropathy, peripheral arterial disease, deformity, ulceration, and infection. Associations were assessed using chi-square tests and independent-samples t-tests, while independent predictors were identified through multivariable logistic regression. Results: The prevalence of diabetic foot syndrome was 28.8% (92/320). Peripheral neuropathy was present in 41.3% and peripheral arterial disease in 29.1% of participants. Patients with DFS had higher age, longer diabetes duration, higher HbA1c, and greater BMI than non-DFS patients. Independent predictors of DFS were peripheral arterial disease (AOR: 6.44, 95% CI: 3.39–12.2), peripheral neuropathy (AOR: 5.82, 95% CI: 3.21–10.5), HbA1c ≥8% (AOR: 3.76, 95% CI: 2.01–7.02), diabetes duration >10 years (AOR: 2.89, 95% CI: 1.54–5.42), and smoking (AOR: 1.92, 95% CI: 1.05–3.54). Conclusion: Diabetic foot syndrome is highly prevalent among poorly controlled T2DM patients and is strongly associated with neuropathy, PAD, poor glycemic control, prolonged diabetes duration, and smoking. Early screening, metabolic optimization, and multidisciplinary diabetic foot care are essential to prevent ulceration, infection, and amputation

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Haider Khan, Sakina Bibi Silachi, Amena Bibi, Aqsa Elahi, Muqaddas Zubair, Hafiz Yaseen Khan, et al. Prevalence and Risk Factors of Diabetic Foot Syndrome in Patients with Poorly Controlled Type 2 Diabetes Mellitus: A Cross-Sectional Analytical Study. JHWCR [Internet]. 2026 May 6 [cited 2026 May 7];4(9):1-10. Available from: https://jhwcr.com/index.php/jhwcr/article/view/1560

References

1. Armstrong DG, Boulton AJM, Bus SA. Diabetic foot ulcers and their recurrence. N Engl J Med. 2017;376(24):2367–2375.

2. International Working Group on the Diabetic Foot. IWGDF guidelines on the prevention and management of diabetic foot disease. 2023.

3. Zhang P, Lu J, Jing Y, Tang S, Zhu D, Bi Y. Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis. Ann Med. 2017;49(2):106–116.

4. Singh N, Armstrong DG, Lipsky BA. Preventing foot ulcers in patients with diabetes. JAMA. 2005;293(2):217–228.

5. Boulton AJM. The diabetic foot: from art to science. Diabetologia. 2004;47(8):1343–1353.

6. Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005;54(6):1615–1625.

7. Prompers L, Huijberts M, Apelqvist J, et al. High prevalence of ischemia, infection and serious comorbidity in patients with diabetic foot disease in Europe. Diabetologia. 2007;50(1):18–25.

8. Stratton IM, Adler AI, Neil HAW, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes: UKPDS 35. BMJ. 2000;321(7258):405–412.

9. Monteiro-Soares M, Boyko EJ, Ribeiro J, et al. Risk stratification systems for diabetic foot ulcers: a systematic review. Diabetes Metab Res Rev. 2011;27(2):119–129.

10. Young MJ, Boulton AJM, MacLeod AF, et al. A multicentre study of the prevalence of diabetic peripheral neuropathy. Diabetologia. 1993;36(2):150–154.

11. Hinchliffe RJ, Brownrigg JRW, Apelqvist J, et al. IWGDF guidance on the diagnosis, prognosis and management of peripheral artery disease in patients with foot ulcers in diabetes. Diabetes Metab Res Rev. 2016;32(Suppl 1):37–44.

12. Tesfaye S, Boulton AJM, Dyck PJ, et al. Diabetic neuropathies: update on definitions and diagnostic criteria. Diabetes Care. 2010;33(10):2285–1293.

13. Bus SA, Lavery LA, Monteiro-Soares M, et al. IWGDF guideline on the prevention of foot ulcers in persons with diabetes. Diabetes Metab Res Rev. 2020;36(S1):e3269.

14. Apelqvist J, Bakker K, van Houtum WH, et al. Practical guidelines on the management and prevention of the diabetic foot. Diabetes Metab Res Rev. 2008;24(S1):S181–S187.

15. Lavery LA, Armstrong DG, Wunderlich RP, et al. Risk factors for foot infections in individuals with diabetes. Diabetes Care. 2006;29(6):1288–1293.

16. Jeffcoate WJ, Harding KG. Diabetic foot ulcers. Lancet. 2003;361(9368):1545–1551.

17. Morbach S, Furchert H, Gröblinghoff U, et al. Long-term prognosis of diabetic foot patients. Diabetes Care. 2012;35(10):2021–2027.

18. Armstrong DG, Cohen K, Courric S, et al. Diabetic foot ulcers and vascular insufficiency. J Vasc Surg. 2011;54(2 Suppl):65S–70S.

19. Willigendael EM, Teijink JAW, Bartelink ML, et al. Smoking and the patency of lower extremity bypass grafts. J Vasc Surg. 2005;42(1):67–74.

20. Wild S, Roglic G, Green A, et al. Global prevalence of diabetes. Diabetes Care. 2004;27(5):1047–1053.

21. Hicks CW, Selvarajah S, Mathioudakis N, et al. Burden of infected diabetic foot ulcers on hospital admissions. Diabetes Care. 2016;39(4):e44–e45.

22. Khan HY, Khan S, Haroon I, Ali I, Ahmed S, Saleem I, Zeeshan M. Sleep quality and its association with level of irritability in patients with frozen shoulder in Peshawar. Indus J Biosci Res. 2025;3(6):129–134.

23. Durrani HI, Rehman M, Khan Y, Hayat F, Memon M, Mujeeb AS, Fazal N, Muhammad SS. Frequency of musculoskeletal disorders among dialysis patients with chronic kidney disease in Institute of Kidney Diseases, Hayatabad Peshawar: a cross-sectional study. J Med Health Sci Rev. 2025;2(2).

24. Khan HY, Khan SH, Gillani A, Gillani A, Yousaf M, Qandeel HS, Daud M. Knowledge, attitudes and beliefs of clinical physiotherapists towards chronic back pain. Natl J Life Health Sci. 2024;3(1):20–24.

25. Khan HY, Adnan M, Basit SA, Khan S, Gul S, Haroon IH, Gull N, Khan N. Evaluation of cervical proprioception and its association with disability in neck pain: a cross-sectional study. Indus J Biosci Res. 2025;3(5):660–664.

26. Khan HY, Tahir A, Andam G, Huma N, Saleem Z. Forward head posture and its association with tension-type headache among bankers of Hayatabad, Peshawar: a cross-sectional study. Natl J Life Health Sci. 2023;2(1):19–22.