Comparison of Intravenous with Oral Iron in Management of Iron Deficiency Anemia in Pregnancy
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Background: Iron deficiency anemia is a common nutritional disorder during pregnancy and is associated with adverse maternal and perinatal outcomes. Oral iron is widely used, but poor adherence, gastrointestinal intolerance, and slow replenishment of iron stores may limit its effectiveness. Objective: To compare the therapeutic effectiveness of intravenous iron sucrose and oral ferrous sulphate in pregnant women with iron deficiency anemia. Methods: This comparative clinical study was conducted in the Department of Obstetrics and Gynecology, Bolan Medical Complex Hospital, Quetta, from October 15, 2024, to April 16, 2025. One hundred pregnant women with iron deficiency anemia were allocated into two equal groups. Group A received oral ferrous sulphate, while Group B received intravenous iron sucrose. Hemoglobin and serum ferritin were measured before treatment and after three weeks. Results: Mean hemoglobin increased from 9.32 ± 0.63 to 10.32 ± 0.62 g/dL in the oral iron group and from 8.82 ± 1.01 to 10.91 ± 1.20 g/dL in the intravenous iron group. The mean hemoglobin rise was greater with intravenous iron than oral iron (2.09 ± 0.51 vs 1.00 ± 0.36 g/dL; p<0.001). Serum ferritin increased by 21.76 ± 5.97 µg/L in the intravenous group compared with 2.95 ± 0.88 µg/L in the oral group (p<0.001). Conclusion: Intravenous iron sucrose was more effective than oral iron in improving hemoglobin and serum ferritin levels in pregnant women with iron deficiency anemia.
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1. Al Hassan NN. The prevalence of iron deficiency anemia in Saudi University female students. J Microsc Ultrastruct. 2015;3(1):25-8.
2. Wali A, Mushtaq A, Nilofer B. Comparative study: efficacy, safety and compliance of intravenous iron sucrose and intramuscular iron sorbitol in iron deficiency anemia of pregnancy. J Pak Med Assoc. 2002;52:392-5.
3. Perewusnyk G, Huch R, Huch A, Breymann C. Parenteral iron therapy in obstetrics: 8 years’ experience with iron-sucrose complex. Br J Nutr. 2002;88:3-10.
4. Hasan S, Hashim B, Sultana A. Iron therapy in iron deficiency anemia in pregnancy: intravenous iron sucrose versus oral iron hydroxide polymaltose complex in anemia. Ann Abbasi Shaheed Hosp Karachi Med Dent Coll. 2003;8:435-40.
5. Bayoumeu F, Subiran-Buisset C, Baka NE, Legagneur H, Monnier-Barbarino P, Laxenaire MC. Iron therapy in iron deficiency anemia in pregnancy: intravenous route versus oral route. Am J Obstet Gynecol. 2002;186:518-22.
6. Tabassum R, Ashfaq S, Khan N. Place of intravenous iron sucrose for the treatment of iron deficiency anemia during pregnancy. Med Channel. 2003;9:55-6.
7. Hercberg S, Galan P, Praul A, Preziosi P. Epidemiology of iron deficiency anemia in the French population. Ann Biol Clin. 1998;56:49-52.
8. World Health Organization. The prevalence of anemia in women: a tabulation of available information. 2nd ed. Geneva: World Health Organization; 1992.
9. Pritchard JA. Hemoglobin regeneration in severe iron deficiency anemia: response to orally and parenterally administered iron preparation. JAMA. 1966;195:717-20.
10. Allen LH. Anemia and iron deficiency: effects on pregnancy outcome. Am J Clin Nutr. 2000;71:1280-4.
11. Mungen E. Iron supplementation in pregnancy. J Perinat Med. 2003;31:420-6.
12. Gravier A, Descargues G, Marpeau L. How to avoid transfusion in postpartum period: importance of an intravenous iron supplement. J Gynecol Obstet Biol Reprod. 1999;28:77-8.
13. Krafft A, Breymann C, Huch R, Huch A. Intravenous iron sucrose in two pregnant women with inflammatory bowel disease and severe iron deficiency anemia. Acta Obstet Gynecol Scand. 2000;79:720-2.
14. Sal Momen AK, Al Meshari A, Al Nuaimen L. Intravenous iron sucrose complex in the treatment of iron deficiency anemia during pregnancy. Eur J Obstet Reprod Biol. 1996;69:121-4.
15. Broche DE, Gay C, Armand-Branger S, Grangeasse L, Terzibachian JJ. Acute postpartum anemia: clinical practice and interest of intravenous iron. Gynecol Obstet Fertil. 2004;32:613-9.
16. Halimi S, Halimi SMA, Sohaib M. Oral versus parenteral iron therapy for correction of iron deficiency anemia in pregnancy. Gomal J Med Sci. 2011;9:3-5.
17. Al RA, Unlubilgin E, Kandemir O, Yalvac S, Cakir L, Haberal A. Intravenous versus oral iron for the treatment of anemia in pregnancy. Obstet Gynecol. 2005;106(6):1335-40.
18. Breymann C, Richter C, Huttner C, Huch R, Huch A. Effectiveness of recombinant erythropoietin and iron sucrose versus iron therapy only in patients with postpartum anemia and blunted erythropoiesis. Eur J Clin Invest. 2000;30:154-61.
19. Zubair S, Mahmud G, Tasnim N. Experience with intravenous iron sucrose in pregnant women. Med Spectr. 2001;22(7-8):27.
20. Soomro MS, Karina KA. Iron binding capacity and transferrin saturation in pregnancy. Pak J Med Sci. 1998;14:315-8.