Efficacy of Hypo fractionated Radiotherapy for Controlling Bleeding and Pain in Locally Advanced Breast Cancer

Authors

  • Kanwal Farid Department of Radiation Oncology, Combined Military Hospital Rawalpindi, Pakistan Author
  • Faryal Kousar Department of Radiation Oncology, Combined Military Hospital Rawalpindi, Pakistan Author
  • Salman Arif Department of Clinical Oncology, Combined Military Hospital (CMH), Rawalpindi, Pakistan Author
  • Usman Ali Department of Clinical Oncology, Combined Military Hospital (CMH), Rawalpindi, Pakistan Author
  • Shahzeb Jawed Department of Radiation Oncology, Combined Military Hospital Rawalpindi, Pakistan Author
  • Aqsa Jadoon Department of Radiation Oncology, Combined Military Hospital Rawalpindi, Pakistan Author

DOI:

https://doi.org/10.61919/axqspm88

Keywords:

Breast Neoplasms, Hypofractionated Radiotherapy, Palliative Care, Pain Management, Hemorrhage, Quality of Life, Radiation Oncology.

Abstract

Background: Locally advanced breast cancer (LABC) often presents with distressing symptoms such as bleeding and pain, significantly impairing patients’ quality of life and complicating the initiation of systemic therapies. Traditional radiotherapy regimens may be unsuitable for patients with limited life expectancy, and there is limited evidence on the role of hypo fractionated radiotherapy in palliating these symptoms in resource limited settings. Objective: To evaluate the efficacy of hypo fractionated radiotherapy in controlling bleeding and pain among patients with locally advanced breast cancer, and to assess symptom resolution across different age groups. Methods: This prospective interventional study was conducted at the Department of Radiation Oncology, CMH Rawalpindi, enrolling 50 female patients with cT4 LABC, aged 20–70 years. Patients received hypo fractionated radiotherapy (3–5 Gy per session, total 30–40 Gy across 6–12 sessions). Symptom status before and after treatment was recorded using a structured questionnaire. Ethical approval was obtained, and all participants gave informed consent in compliance with the Declaration of Helsinki. Data were analyzed using SPSS v25, applying descriptive statistics and chi-square tests for stratified analysis. Results: The mean age of participants was 41.06 ± 9.14 years. Post-treatment, bleeding was resolved in 82% and pain in 76% of patients. Stratification by age showed no statistically significant differences in bleeding (p = 0.719) or pain (p = 0.620) resolution, indicating consistent efficacy across age groups. Conclusion: Hypo fractionated radiotherapy is a clinically effective and well-tolerated palliative option for managing bleeding and pain in LABC, improving patient comfort and supporting its integration into real-world palliative care pathways.

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Published

2025-04-24

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Section

Articles

How to Cite

1.
Kanwal Farid, Faryal Kousar, Salman Arif, Usman Ali, Shahzeb Jawed, Aqsa Jadoon. Efficacy of Hypo fractionated Radiotherapy for Controlling Bleeding and Pain in Locally Advanced Breast Cancer. JHWCR [Internet]. 2025 Apr. 24 [cited 2025 Aug. 23];:e103. Available from: https://jhwcr.com/index.php/jhwcr/article/view/103