Role of Dapoxetine in Premature Ejaculation
DOI:
https://doi.org/10.61919/e6wn3q58Keywords:
Premature ejaculation, dapoxetine, intravaginal ejaculation latency time, selective serotonin reuptake inhibitors, sexual dysfunction, PakistanAbstract
Background: Premature ejaculation (PE) is a prevalent male sexual dysfunction that significantly impacts psychological wellbeing and relationship satisfaction. While traditionally managed with behavioral interventions, pharmacologic therapies—particularly selective serotonin reuptake inhibitors—have emerged as effective alternatives. Dapoxetine, a short-acting SSRI, is approved for on-demand treatment of PE and has demonstrated efficacy in prolonging intravaginal ejaculation latency time (IELT), yet data from South Asian populations remain limited. Objective: To determine the effectiveness of dapoxetine 30 mg in increasing IELT among men diagnosed with premature ejaculation in a tertiary care setting in Pakistan. Methods: This descriptive observational study included 165 male patients aged 20–60 years with clinically diagnosed PE, based on DSM-V criteria, treated with dapoxetine 30 mg on demand over 12 weeks. IELT was self-recorded using a stopwatch. Effectiveness was defined as achieving IELT >1 minute in ≥75% of sexual encounters. Data were analyzed using SPSS v25. Stratified analyses were conducted by age, BMI, and symptom duration. Results: The mean age was 39.25 ± 11.71 years, and mean BMI was 25.75 ± 1.09 kg/m². The mean pre-treatment and post-treatment IELT were 1.53 ± 0.50 and 3.16 ± 1.41 minutes, respectively, with a significant mean increase of 1.63 minutes (p < 0.001). Overall, 106 patients (64.2%) achieved treatment effectiveness. No significant differences were found across stratified subgroups (p > 0.05). Conclusion: Dapoxetine 30 mg demonstrated a statistically and clinically significant improvement in IELT in men with PE, with consistent effectiveness across age, BMI, and symptom duration strata. These findings support its role as an effective on-demand therapy for premature ejaculation in the regional population.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Sadeed Ullah ., Ismail Khan, Hamza Khan, Raz Muhammad (Author)

This work is licensed under a Creative Commons Attribution 4.0 International License.