Role of Dapoxetine in Premature Ejaculation

Authors

  • Sadeed Ullah Department of Urology, MTI/LRH, Peshawar, Pakistan Author
  • Ismail Khan Department of Urology, MTI/LRH, Peshawar, Pakistan Author
  • Hamza Khan Department of Urology, MTI/LRH, Peshawar, Pakistan Author
  • Raz Muhammad Department of Urology, MTI/LRH, Peshawar, Pakistan Author

DOI:

https://doi.org/10.61919/e6wn3q58

Keywords:

Premature ejaculation, dapoxetine, intravaginal ejaculation latency time, selective serotonin reuptake inhibitors, sexual dysfunction, Pakistan

Abstract

Background: Premature ejaculation (PE) is a prevalent male sexual dysfunction that significantly impacts psychological wellbeing and relationship satisfaction. While traditionally managed with behavioral interventions, pharmacologic therapies—particularly selective serotonin reuptake inhibitors—have emerged as effective alternatives. Dapoxetine, a short-acting SSRI, is approved for on-demand treatment of PE and has demonstrated efficacy in prolonging intravaginal ejaculation latency time (IELT), yet data from South Asian populations remain limited. Objective: To determine the effectiveness of dapoxetine 30 mg in increasing IELT among men diagnosed with premature ejaculation in a tertiary care setting in Pakistan. Methods: This descriptive observational study included 165 male patients aged 20–60 years with clinically diagnosed PE, based on DSM-V criteria, treated with dapoxetine 30 mg on demand over 12 weeks. IELT was self-recorded using a stopwatch. Effectiveness was defined as achieving IELT >1 minute in ≥75% of sexual encounters. Data were analyzed using SPSS v25. Stratified analyses were conducted by age, BMI, and symptom duration. Results: The mean age was 39.25 ± 11.71 years, and mean BMI was 25.75 ± 1.09 kg/m². The mean pre-treatment and post-treatment IELT were 1.53 ± 0.50 and 3.16 ± 1.41 minutes, respectively, with a significant mean increase of 1.63 minutes (p < 0.001). Overall, 106 patients (64.2%) achieved treatment effectiveness. No significant differences were found across stratified subgroups (p > 0.05). Conclusion: Dapoxetine 30 mg demonstrated a statistically and clinically significant improvement in IELT in men with PE, with consistent effectiveness across age, BMI, and symptom duration strata. These findings support its role as an effective on-demand therapy for premature ejaculation in the regional population.

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Published

2025-07-16

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Articles

How to Cite

1.
Sadeed Ullah, Ismail Khan, Hamza Khan, Raz Muhammad. Role of Dapoxetine in Premature Ejaculation. JHWCR [Internet]. 2025 Jul. 16 [cited 2025 Aug. 24];:e590. Available from: https://jhwcr.com/index.php/jhwcr/article/view/590

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