Accuracy of Raised Maternal Total Leukocyte Count for the Diagnosis of Chorioamnionitis in Patients Presenting with Preterm Prelabour Rupture of Membrane to a Tertiary Care Hospital
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Introduction: Scabies is a highly contagious parasitic infestation predominantly affecting children in resource-limited settings. Both topical permethrin 5% cream and benzyl benzoate 25% lotion are used in clinical practice, yet comparative data in the pediatric population from local tertiary care settings remain limited. Objective: To compare the efficacy and safety of topical permethrin 5% cream with topical benzyl benzoate 25% lotion in children with scabies presenting to a tertiary care dermatology centre. Study Design: Quasi-experimental study. Setting: Department of Dermatology, Mayo Hospital, Lahore. Duration: 1st January 2024 to 31st December 2024. Subjects and Methods: A total of 150 children aged 3–14 years with clinically diagnosed scabies were enrolled and allocated by alternate assignment to two groups of 75 each. Group A received topical permethrin 5% cream and Group B received topical benzyl benzoate 25% lotion. Clinical cure rates, time to pruritus resolution, and local adverse effects were assessed at 2 and 4 weeks following the first application. Results: At 2 weeks, clinical cure was achieved in 68 (90.7%) patients in Group A compared with 54 (72.0%) in Group B (p=0.006). At 4 weeks, cure rates were 96.0% and 84.0% respectively (p=0.023). Mean time to pruritus resolution was significantly shorter in Group A (8.1 ± 2.3 days vs 11.9 ± 3.4 days, p<0.001). Any adverse effect was recorded in 20.0% of Group A versus 50.7% of Group B (p<0.001). Conclusion: Topical permethrin 5% cream demonstrated superior efficacy and a more favorable safety profile compared with benzyl benzoate 25% lotion in children with scabies and is recommended as the preferred first-line scabicidal agent in this population.
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